Professor Véronique Gouverneur

Tutor in Organic Chemistry, Professor of Chemistry
Research

Professor Gouverneur’s interdisciplinary research lies at the interface of chemistry and medicine. She is specialised in fluorine chemistry with a focus on late stage fluorination using both the naturally occurring isotope 19F and the cyclotron-produced positron emitting radioisotope 18F. These advances have found direct applications in the pharmaceutical sector and in clinical imaging, particularly Positron Emission Tomography (PET). Her approach to PET 18F-radiochemistry, being distinct from conventional practices, has granted access to radioactive tracers that had been too difficult or impossible to prepare, thereby unlocking and accelerating diagnostic and drug discovery programmes.

Teaching

Synthetic organic chemistry, asymmetric synthesis and catalysis, biosynthesis of natural products, biological chemistry, fluorine chemistry.

Publications

Asymmetric Nucleophilic Fluorination Under Hydrogen Bonding Phase-Transfer Catalysis, G. Pupo, F. Ibba, D. M. H. Ascough, A. C. Vicini, P. Ricci, K. E. Christensen, L. Pfeifer, J. R. Morphy, J. M. Brown, R. S. Paton, V. Gouverneur Science 2018, 360, 638–642.

18F-Trifluoromethylation of Unmodified Peptides with 5-18F-(Trifluoromethyl)dibenzothiophenium Trifluoromethanesulfonate, S Verhoog, C Kee, Y Wang, T Khotavivattana, T Wilson, V Kersemans, S Smart, M Tredwell, B Davis and V Gouverneur J. Am. Chem. Soc. 2018, 7, 1572–1575.

De-Risking the Cu-Mediated 18F-Fluorination of Heterocyclic PET Radioligands N. Taylor, E. Emer, S. Preshlock, M. Schedler, M. Tredwell, S. Verhoog, J. Mercier, C. Genicot, and V. Gouverneur J. Am. Chem. Soc. 2017, 139, 8267–8276.

Bridging The Gaps In 18F PET Tracer Development M. G. Campbell, J. Mercier, C. Genicot, V. Gouverneur, J. M. Hooker, T. Ritter Nature Chemistry 2017, 9, 1–3.

A Broadly Applicable [18F]Trifluoromethylation of Aryl and Heteroaryl Iodides for PET Imaging M. Huiban, M. Tredwell, S. Mizuta, Z. Wan, X. Zhang, T. Lee Collier, V. Gouverneur,* J. Passchier* Nature Chemistry 2013 5, 941–944.