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Professor Nicole Zitzmann

Research Fellow in Biochemistry, Stipendiary Lecturer in Biochemistry

Subject

Biochemistry
Virology

Research

Dengue virus, Hepatitis C virus (HCV), human immunodeficiency virus (HIV) and Hepatitis B virus (HBV) collectively infect more than 550 million people worldwide. My group is developing antiviral therapies and methods of drug delivery to combat these and other viruses such as Ebola.

We are focusing in particular on interfering with the morphogenesis of HCV and HIV, on the host cytokine response to dengue virus infection, the structural biology of viral proteins as well as host cell proteins needed for the formation of infectious viruses, and the development of a mass spectrometry based non-invasive diagnostic test for early stages of liver fibrosis (caused by HCV).

To achieve this, we have a number of national and international, academic, medical and industry partners. Members of my group are involved in many interdisciplinary projects, using proteomics, mass spectrometry, lipidomics, phage display, x-ray crystallography, electron microscopy (EM), nuclear magnetic resonance (NMR), electrophysiological techniques, organic and medicinal chemistry, atomistic computer modelling, and of course, growing and killing viruses.

Teaching Interests

Virology, Glycobiology, Biochemistry

At Merton, I teach Biochemistry to 1st B.M. medical students.